p 130: the role of host t- cell lymphocyte in immunopathogenesis of htlv-i-associated myelopathy/tropical spastic paraparesis
نویسندگان
چکیده
human t-cell lymphotropic virus type 1 (htlv-1) is associated with adult t-cell leukemia/lymphoma (atl) and htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp). only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic and ham/tsp is the most common clinical manifestation of the virus. ham/tsp is an inflammatory disease of the central nervous system (cns). the mechanism by which htlv-1 induces ham/tsp is not clear yet. several factors have been hypothesized to contribute to an htlv-i-infected individual’s progress to ham/tsp. one of the most important factors is the host immune response against htlv-i and t cell lymphocytes plays a key role in the immune response against htlv1 virus. htlv1 attacks different types of cells in the body but cd4(+) t lymphocytes are the main target of htlv-1 that have an important role in the immunological response to this retrovirus. htlv-i-infected cd4+ t lymphocytes migrate to the cns tissues and cd8+ htlv-i specific cytotoxic t lymphocyte (ctl) attack htlv-i-infected lymphocytes. recent data indicate that htlv-i and its expression are localized in infiltrated lymphocytes within the spinal cord lesions of ham/tsp patients rather than in resident central nervous system (cns) parenchymal cells. hyperactive cd8(+) cytotoxic t lymphocytes (ctl) that generate in response to htlv-i-infected lymphocytes likely play a key role in the genesis of pathologic abnormalities associated with ham/tsp and also a high htlv-i proviral load in peripheral blood lymphocytes (pbl) increase this pathological response and cause spinal cord lesions in ham/tsp patients. although the exact mechanism underlying the high htlv-i proviral load in pbl in ham/tsp patients is still unknown, we must consider therapeutic approaches in ham/tsp that eliminate htlv-i-infected cd4+ t lymphocytes and also the regulation of efficiency and activity of hyperactive cd8 (+) cytotoxic t lymphocyte (ctl).
منابع مشابه
P 130: The Role of Host T- Cell Lymphocyte in Immunopathogenesis of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis
Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic and HAM/TSP is the most common clinical manifestation of the virus. HAM/TSP is an inflamma...
متن کاملThe Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the v...
متن کاملPolymorphism in the interleukin-10 promoter affects both provirus load and the risk of human t lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
متن کاملPolymorphism in the interleukin-10 promoter affects both provirus load and the risk of human t lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
متن کاملPain in tropical spastic paraparesis/HTLV-I associated myelopathy patients.
OBJECTIVE Tropical Spastic Paraparesis/HTLV-I Associated Myelopathy (TSP/HAM) is a chronic myelopathy, and pain has been mentioned as a frequent sensory symptom in this condition. The authors aimed at analyzing this symptom in a TSP/HAM patients series. METHOD For this, 46 patients were analyzed considering demographic and clinical characteristics and complaint of pain as to verbal descriptio...
متن کامل[HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)].
Human T lymphotropic virus type I(HTLV-I) is associated with the nonfatal neurologic disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Many clinical signs of involvement outside the central nervous system (CNS) have been described in some patients with HAM/TSP and have triggered the discovery of some HTLV-I-associated concepts in the infected individuals without sign...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
مجله علوم اعصاب شفای خاتمجلد ۵، شماره ۲، صفحات ۱۶۱-۱۶۱
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023